Identifying autoantibody biomarkers derived
from cancer-specific splicing and validating them in
pre-clinical and occult ovarian cancer plasma samples (PI:
McIntosh): This Department of Defense funded project
mines mRNA-seq data to identify ovarian cancer selective
transcripts, and perform stimulated ELISPOT assays using PBMCs
from those transcripts to determine whether proteins contain
epitopes recognized by their CD8+ T Cells.
Predicting HIV-Associated Kaposi Sarcoma with Proteins and Autoantibodies (PI: McIntosh): This NIH-funded project aims to identify blood protein biomarkers that can detect individuals who are at imminent risk for developing KS in HIV+/HHV-8+ populations.
Biomarker validation for ovarian early detection markers. Pacific Ovarian Cancer Research Consortium (POCRC) (Project lead McIntosh, PI: Urban): This research represents the early detection project on the FHCRC Ovarian Cancer SPORE, an NCI-funded translational research program. This project intends to confirm individual analytes of interest for ovarian cancer molecular diagnostics.